Genetics (GEN)

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GEN 804 - Genetics of Prokaryotic Microbes

Credits: 5

Maintenance, exchange, and expression of genetic material in bacteria and their viruses. Historical overview of the role microbial genetics played in development of modern molecular biology. Contemporary perspective on methods used to understand the function of genes and their applications to basic science, biomedical research, and biotechnology. Prereq: introductory microbiology with lab; introductory genetics; or permission. Lab. Special fee.

Equivalent(s): BCHM 754, BCHM 854, GEN 754, GEN 854, MICR 704, MICR 804, PBIO 754, PBIO 854

GEN 805 - Population Genetics

Credits: 3

Exploration of the forces (mutation, selection, random drift, inbreeding, assortative mating) affecting the frequency and distribution of genetic variation in natural populations. Quantifying the structure of populations. Methods of analysis for theoretical and practical applications. Prereq: Introductory Genetics and Statistics.

Equivalent(s): ZOOL 805

GEN 806 - Human Genetics

Credits: 4

Genetic basis of human traits and diseases including both traditional methods of diagnosis and contemporary molecular genetic approaches stemming from the human genome project. Case studies exemplify common practices in human genetic counseling and integrate the scientific basis of diagnosis with the special ethical implications of human genetic analysis. Prereq: introductory genetics or permission.

Equivalent(s): ANSC 806

GEN 811 - Genomics and Bioinformatics

Credits: 4

Methods, applications, and implications of genomics—the analysis of whole genomes. Microbial, plant and animal genomics are addressed. Medical, ethical and legal implications of genomic data. Computer lab provides exposure and experience in a range of bioinformatics approaches used in genome analysis. Prereq: introductory genetics. Computer lab.

Equivalent(s): BCHM 811, MICR 811

GEN 812 - Programming for Bioinformatics

Credits: 5

Development of programming skills that enable life science students to ask fundamental biological questions that require computers to automate repetitive tasks and handle query results efficiently. Topics include: computer values of important parameters of biological sequence data; pattern search and motif discovery scripts; accessing, querying, manipulating, retrieving, parsing, analyzing, and saving data from local and remote databases. Prereq: introductory genetics; introductory bioinformatics; or permission. Computer Lab.

GEN 813 - Microbial Ecology and Evolution

Credits: 4

Evolutionary and ecological forces that generate the tremendous diversity of microbial life on Earth with emphasis on viruses, archaea and bacteria. Functional roles of microorganisms, their population dynamics and interactions, and their mechanisms of evolutionary change in a variety of environmental settings, including natural communities and laboratory microcosms. Prereq: introductory genetics; introductory microbiology and lab; or permission.

Equivalent(s): MICR 813

GEN 815 - Molecular Evolution

Credits: 4

Rates and patterns of evolutionary change in biomolecules. Forces affecting the size and structure of genomes. Molecular mechanisms of organismal evolution. Emphasizes integrating evidence from biochemistry, molecular genetics and organismal studies. Methods for reconstructing phylogeny from molecular sequences. Prereq: introductory genetics. Some knowledge of statistics recommended. Computer lab.

Equivalent(s): ZOOL 815

GEN 817 - Molecular Microbiology

Credits: 5

Fundamental physiological and metabolic processes of archaea bacteria and fungi with a strong emphasis on prokaryotes. Literature-based course with lab. Topics include regulation and coordination of microbial metabolism, bacterial cell cycle, global control of gene expression, signal transduction, and microbial cell differentiation. Prereq: introductory microbiology and lab; introductory genetics; or permission. Special fee. Lab.

Equivalent(s): MICR 817

GEN 821 - Comparative Genomics

Credits: 4

Explores the central questions and themes in contemporary comparative genomics, including genome biology, phylogenomics, human origins, population genomics, and ecological genomics. Provides the conceptual framework required to evaluate new work in this fast-changing field. Prereq: introductory genetics.

GEN 825 - Population Genetics Lab

Credits: 2

Hands-on approach to exploration of evolutionary forces affecting the frequency and distribution of genetic variation in natural populations. Wet lab techniques include DNA extraction, restriction enzyme digestion, PCR, DNA fragment size-selection. Computational skills include high-throughput sequencing data control, identifying allelic variants, and generation of population genetic summary statistics. Prereq: Introductory Genetics and Statistics.

Co-requisite: GEN 805

GEN 871 - Molecular Genetics

Credits: 4

Structure, organization, replication, dynamics, and expression of genetic information in eukaryotes. Focus on molecular genetic and epigenetic mechanisms of gene expression and its control; molecular genetic control of cell division and differentiation during development. Prereq: introductory genetics.

Equivalent(s): BCHM 871

GEN 872 - Evolutionary Genetics of Plants

Credits: 4

Mechanisms of genetic change in plant evolution, both in nature and under human influence. Topics include neo-Darwinian theory; speciation and hybridization; origins and co-evolution of nuclear and organelle genomes; gene and genome evolution; transposable elements; chromosome rearrangements; polyploidy; genetic modification. Lab introduces methods in information gathering, bioinformatics, genome analysis, plant breeding, and genetic manipulation. Prereq: introductory genetics. Lab. Special fee.

Equivalent(s): PBIO 872

GEN 874 - Techniques in Plant Genetic Engineering and Biotechnology

Credits: 4

Theory and hands-on experience with techniques used in plant genetic engineering, including cell and tissue culture, gene cloning, and analysis of foreign gene expression. Discussion of role of plant biotechnology in sustainable agriculture and climate change; modifying plants for better nutrition and stress response, environmental remediation, and for production of pharmaceuticals; controversies associated with this technology. Lab. Special fee. Prereq: introductory genetics or permission.

Equivalent(s): PBIO 874